Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in kidney and liver function after methoxyflurane (penthrane) anaesthesia.

B E Dahlgren, B H Goodrich

    British Journal of Anaesthesia
    |February 1, 1976
    PubMed
    Summary

    Methoxyflurane anesthesia may cause transient kidney and liver dysfunction in patients. This study found impaired kidney and liver function even at doses previously considered safe, highlighting potential toxicity risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Portable, but suitable: devices in prehospital care might be hazardous to patient or to aviation safety.

    Prehospital and disaster medicine·1996
    Same author

    [Helicopters of the Swedish Department of Defense--a limited resource].

    Lakartidningen·1990
    Same author

    Tracheal tubes in cold stress.

    Anaesthesia·1988
    Same author

    Appropriate suction device in rescue medicine.

    Annals of emergency medicine·1987
    Same author

    Public opinion on the ambulance service in a rural and an urban region.

    Scandinavian journal of social medicine·1986
    Same author

    Portable emergency ventilators. 2. Sensitivity to environment.

    Acta anaesthesiologica Scandinavica·1985

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Toxicology

    Background:

    • Methoxyflurane, halothane, and pethidine are anesthetic agents.
    • Thiopentone and suxamethonium are used for induction.
    • Previous understanding suggested low-dose methoxyflurane was safe.

    Purpose of the Study:

    • To compare the effects of methoxyflurane, halothane, and pethidine on kidney and liver function.
    • To investigate potential toxicity of methoxyflurane at doses below 16 ml.

    Main Methods:

    • Three patient groups received different anesthetic agents post-induction.
    • Multivariate Student t tests with simultaneous confidence intervals were employed.
    • Kidney function markers (uric acid, creatinine, BUN, sodium) and liver function markers (SGPT, SGOT, alkaline phosphatase, bilirubin) were analyzed.

    Related Experiment Videos

    Main Results:

    • Methoxyflurane group showed significant differences in kidney function markers compared to other groups.
    • Methoxyflurane group also exhibited significant differences in liver function markers.
    • These effects were observed at methoxyflurane doses under 16 ml.

    Conclusions:

    • Methoxyflurane anesthesia can lead to transient kidney and liver impairment.
    • Doses of methoxyflurane below 16 ml may possess toxic effects.
    • Clinical practice should consider these potential adverse effects of methoxyflurane.