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Estrogen-like effect and cytotoxicity of chemical compounds
1Advanced Technology Laboratory, Kubota Corporation, 5-6 Kouyoundai, Ryuugasaki, Ibaraki pref., 301-0852 Japan.
Abstract:
Luciferase assay, cytotoxicity test and protein quantitative analysis were performed after the exposure of chemical compounds to MVLN cells that are utilized to detect the endocrine disrupting activity. These consequences indicate that the concentration is different between the estrogen receptor mediated proliferation of breast cancer cells and the estrogen receptor mediated transcription by chemical compounds.