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Related Experiment Videos

Multiple elements within the Xic regulate random X inactivation in mice.

Philippe Clerc1, Philip Avner

  • 1Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France. pclerc@pasteur.fr

Seminars in Cell & Developmental Biology
|January 14, 2003
PubMed
Summary
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X-chromosome inactivation silences one X chromosome in female mammals. The X-inactivation center (Xic) and its Xist gene regulate this complex process, coordinating gene silencing with development.

Area of Science:

  • Genetics
  • Developmental Biology
  • Molecular Biology

Background:

  • Female mammals silence most genes on one X chromosome via X-chromosome inactivation.
  • The X-inactivation center (Xic) on the X chromosome controls this process.
  • The Xist gene within the Xic is crucial for initiating transcriptional repression.

Purpose of the Study:

  • To review current knowledge of regulatory elements within the mouse Xic.
  • To explore the mechanisms governing random X inactivation.

Main Methods:

  • Review of existing literature on X-chromosome inactivation.
  • Analysis of regulatory elements and gene function within the mouse Xic.

Main Results:

  • The Xic orchestrates a complex program for X inactivation.

Related Experiment Videos

  • Xist RNA plays a central role in establishing gene silencing.
  • The Xic coordinates X inactivation with sex determination and embryonic development.

    • Conclusions:

    • Understanding the mouse Xic's regulatory elements is key to deciphering X inactivation.
    • Mechanisms underlying random X inactivation are intricate and linked to development.