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Related Experiment Videos

Sperm chromosomal abnormalities are linked to sperm morphologic deformities.

Iwan Lewis-Jones1, Nabil Aziz, Srividya Seshadri

  • 1Department of Obstetrics and Gynaecology, The University of Liverpool, Liverpool, United Kingdom.

Fertility and Sterility
|January 14, 2003
PubMed
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Specific sperm defects, such as double heads or multiple nuclei, are linked to higher rates of chromosomal abnormalities in sperm. This finding suggests caution with in vitro fertilization (IVF) due to risks of embryonic aneuploidy.

Area of Science:

  • Reproductive biology
  • Human genetics
  • Medical diagnostics

Background:

  • Sperm morphology assessment is a routine part of male infertility evaluation.
  • Chromosomal abnormalities in sperm can lead to infertility and developmental issues in offspring.
  • Fluorescence in situ hybridization (FISH) allows for the detection of aneuploidy in sperm.

Observation:

  • This case report examined three infertile men with severe oligoasthenospermia and total teratozoospermia.
  • Morphological analysis revealed a high incidence of sperm with double heads, multinucleated heads, and multiple tails.
  • Interphase FISH analysis was used to assess aneuploidy for chromosome 18 and sex chromosomes.

Findings:

  • All three patients exhibited a high proportion of sperm with chromosomal abnormalities, including disomy, trisomy, and tetrasomy for chromosome 18 and sex chromosomes.

Related Experiment Videos

  • Normal hormone profiles and peripheral lymphocyte karyotypes were observed in the patients.
  • A strong association was found between specific sperm morphologic abnormalities and increased sperm chromosomal abnormalities.

    • Implications:

    • Specific sperm morphology defects may indicate underlying sperm aneuploidy.
    • Assisted reproductive technologies like in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) should be approached cautiously in such cases.
    • There is a significant risk of embryonic aneuploidy and chromosomal abnormalities in offspring conceived via IVF/ICSI when sperm morphology is severely compromised.