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Updated: Aug 14, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
[Correlation and significance of E-cadherin and N-cadherin expression in prostate cancer]
Xiao Huang1, Li-qun Zhou, Jun-kui Ai
1Department of Urology, First Affiliated Hospital, Pebing University, Beijing 100034, P. R. China.
Background & Objective:
Decreased expression of E-Cadherin correlated with many kinds of cancer, but inappropriate expression of N-cadherin has been reported in breast cancer recently, which has a more distinct and direct role in promoting cancer cell motility than E-cadherin. The aim of this study was to investigate the correlation between E-Cadherin and N-Cadherin expression with the grade and stage of prostate cancer and their relationship with prostate specific antigen (PSA).
Methods:
E-Cadherin and N-Cadherin expression in 56 prostate cancer samples were determined by immunohistochemical staining.
Results:
Twenty-four patients (43%) were positive and 32 patients (57%) were negative in E-Cadherin expression. Eighteen patients (32%) were negative and 38 patients (68%) were positive in N-Cadherin expression. E-Cadherin and N-Cadherin were significantly related to the grade and stage of cancer and the change of F/T ratio (free prostate specific antigen/total prostate specific antigen ratio). There was no significant relationship between Cadherin expression and total prostate specific antigen (tPSA) or free prostate specific antigen (fPSA).
Conclusion:
E-Cadherin and N-Cadherin abnormal expressions may serve as the indicators to malignant degree and prognosis of the prostate cancer.
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