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Bupropion poisoning: a case series.

Corrine R Balit1, Christa N Lynch, Geoffrey K Isbister

  • 1NSW Poisons Information Centre, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. Corrinebalit@aol.com

The Medical Journal of Australia
|January 16, 2003
PubMed
Summary

Bupropion hydrochloride overdose in adults can cause significant effects like seizures and hypertension. Accidental ingestion by children resulted in minimal symptoms, indicating a notable difference in toxicity between age groups.

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Area of Science:

  • Clinical Toxicology
  • Pharmacology
  • Emergency Medicine

Background:

  • Bupropion hydrochloride is a widely prescribed antidepressant.
  • Overdose cases require understanding of potential toxic effects and management strategies.

Purpose of the Study:

  • To assess the toxicity of bupropion hydrochloride in adult self-poisoning and pediatric accidental ingestion.
  • To document clinical effects, adverse outcomes, and treatments in bupropion overdose cases.

Main Methods:

  • Prospective study of cases reported to the New South Wales Poisons Information Centre (NSW PIC).
  • Inclusion of 59 adults and 10 children with bupropion exposure from November 2000 to July 2001.
  • Follow-up via hospital medical records to ascertain clinical effects and outcomes.

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Main Results:

  • Adult bupropion overdose commonly caused sinus tachycardia (83%), hypertension (56%), seizures (37%), and agitation (32%).
  • Seizures were dose-dependent and self-limiting; no adult deaths were reported.
  • Pediatric accidental ingestion led to mild symptoms, primarily vomiting and hallucinations in one case.

Conclusions:

  • Bupropion hydrochloride overdose presents significant clinical toxicity in adults.
  • Accidental ingestion in children appears to have a lower risk of severe adverse events.