Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recognition memory and the human hippocampus.

Joseph R Manns1, Ramona O Hopkins, Jonathan M Reed

  • 1University of California, San Diego, La Jolla, CA 92093, USA.

Neuron
|January 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.

Communications biology·2026
Same author

Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Mind's eye: Saccade-related evoked potentials support visual encoding in humans.

medRxiv : the preprint server for health sciences·2025
Same author

Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.

bioRxiv : the preprint server for biology·2025
Same author

Executive Summary: Society of Critical Care Medicine Guidelines on Family-Centered Care for Adult ICUs.

Critical care medicine·2025
Same author

Society of Critical Care Medicine Guidelines on Family-Centered Care for Adult ICUs: 2024.

Critical care medicine·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Declarative memory relies on the medial temporal lobe. This study shows hippocampal damage impairs recognition memory, affecting both recollection and familiarity.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Medical Research

Background:

  • Declarative memory, essential for recalling facts and events, is critically dependent on the medial temporal lobe, including the hippocampal region.
  • Recognition memory, a key aspect of declarative memory, involves identifying previously encountered information and relies on processes like recollection and familiarity.
  • The precise role of the hippocampal region in recognition memory, particularly in distinguishing between recollection and familiarity, remains an area of active investigation.

Purpose of the Study:

  • To investigate the necessity of the hippocampal region for intact recognition memory.
  • To determine the specific contribution of the hippocampal region to the processes of recollection and familiarity within recognition memory.

Main Methods:

Related Experiment Videos

  • Studied seven patients with bilateral hippocampal region damage.
  • Administered three standard tests of recognition memory.
  • Assessed performance on 'Remembering' (episodic recollection) and 'Knowing' (familiarity) measures.

    • Main Results:

    • Patients with hippocampal region damage exhibited significant impairments across all three recognition memory tests.
    • The observed deficits in recognition memory were comparable for both the 'Remembering' (episodic recollection) and 'Knowing' (familiarity) components.
    • These findings suggest a critical role for the hippocampal region in supporting both recollection and familiarity-based recognition.

    Conclusions:

    • The hippocampal region is crucial for successful recognition memory.
    • The hippocampal region contributes to both the ability to recollect specific learning episodes and the sense of familiarity with encountered items.
    • Damage limited to the hippocampal region significantly impacts multiple facets of recognition memory.