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Genomic variability among enteric pathogens: the case of the mutS-rpoS intergenic region
Michael L Kotewicz1, Eric W Brown, J Eugene LeClerc
1Division of Molecular Biology, Center for Food Safety & Applied Nutrition, US Food and Drug Administration, MOD-1, 8301 Muirkirk Road, Laurel, MD 20708, USA.
Trends in Microbiology
|January 16, 2003
Abstract:
The mutS-rpoS intergenic region of enteric bacteria ranges in size from 88 bp in Yersinia to > 12000 bp in Salmonella. We interpret this expansion as the result of the horizontal transfer of segments of DNA from diverse origins. Both comparative genomic analysis and selective sequencing of a variety of Escherichia coli pathogens have provided additional evidence for reassortment of segments within this region.