Jove
Visualize
Contact Us

Related Experiment Videos

Nosocomial pneumonia.

Waldemar G Johanson1, Lisa L Dever

  • 1UMDNJ-New Jersey Medical School, 185 South Orange, Newark, NJ 07018, USA. buzzjoh@comcast.net

Intensive Care Medicine
|January 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ocular MPox: A report of two cases.

IDCases·2023
Same author

Mycobacterium abscessus Periprosthetic Hip Infection Complicated by Superimposed Polymicrobial Infection: A Case Report.

JBJS case connector·2021
Same author

Brevibacteria tibial osteomyelitis.

IDCases·2021
Same author

Micromonas micros: A rare anaerobic cause of late implant failure following spinal surgery.

The journal of spinal cord medicine·2019
Same author

Case Report: Mucocutaneous Leishmaniasis Masquerading as Idiopathic Midline Granulomatous Disease.

The American journal of tropical medicine and hygiene·2019
Same author

Bezold's abscess: A rare complication of suppurative mastoiditis.

IDCases·2019
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Nosocomial pneumonia stems from microaspiration in patients with weakened defenses. Invasive diagnostic techniques like the protected specimen brush (PSB) accurately identify lung infections, offering a gold standard for diagnosis.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Critical Care Medicine

Background:

  • Nosocomial pneumonia, previously termed terminal pneumonia, arises from microaspiration of oropharyngeal secretions.
  • Impaired host defenses and the impact of antimicrobial agents contribute to its development.
  • Antibiotic use alters flora, favoring resistant gram-negative bacilli, while critically ill patients are susceptible to exogenous colonization.

Observation:

  • Clinical signs for diagnosing respiratory infections are often unreliable for nosocomial pneumonia.
  • Invasive diagnostic methods are crucial for accurate bacterial burden assessment.
  • The protected specimen brush (PSB) technique minimizes contamination from secretions.

Findings:

  • The PSB technique accurately reflects the bacterial burden in the lungs.

Related Experiment Videos

  • Quantitation of PSB specimens serves as a reliable proxy for direct lung cultures.
  • PSB analysis is considered the current gold standard for diagnosing nosocomial pneumonia.

    • Implications:

    • Accurate diagnosis of nosocomial pneumonia is essential for effective treatment.
    • Invasive techniques improve diagnostic specificity compared to traditional methods.
    • Understanding the pathophysiology aids in developing targeted prevention and treatment strategies.