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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
[Mild Cognitive Impairment: potential therapeutics]
H Allain1, D Bentue-Ferrer, S Belliard
1Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine, Université de Rennes I, CS 34317, 35043 Rennes Cedex.
Abstract:
Mild Cognitive Impairment (MCI) is an emerging concept used to describe memory decline and probably attention disturbances in otherwise intellectually intact individuals. MCI may be considered in 12 to 15 p. 100 of the cases as announcing an Alzheimer's Disease (AD). Although still speculative, the debate concerning the drugs susceptible to normalize symptoms of MCI or to stop conversion to AD must be raised. For that purpose, several long term clinical trials are running (antioxidants, nootropics, anticholinesterasics.) and new molecules in the pipe-line should be assessed in patients with the diagnosis of MCI.
Insights
Mild Cognitive Impairment (MCI) involves memory decline in individuals. Research is exploring drugs to manage MCI symptoms and prevent progression to Alzheimer's Disease (AD).
Area of Science:
- Neurology
- Gerontology
- Pharmacology
Background:
- Mild Cognitive Impairment (MCI) signifies memory decline and attention issues in cognitively intact individuals.
- MCI is observed in 12-15% of cases and may precede Alzheimer's Disease (AD).
Purpose of the Study:
- To discuss potential pharmaceutical interventions for MCI.
- To review ongoing clinical trials and future drug assessments for MCI management.
Main Methods:
- Review of current research and clinical trial data for MCI treatments.
- Assessment of drug pipelines for potential efficacy in MCI patients.
Main Results:
- Several long-term clinical trials are investigating various drug classes including antioxidants, nootropics, and anticholinesterases.
- New molecules are in development for future assessment in MCI patients.
Conclusions:
- The development of drugs to normalize MCI symptoms or halt progression to AD is under active investigation.
- Further research and clinical trials are essential to evaluate new therapeutic strategies for MCI.
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