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[Morphological aspects of heart remodeling in chronic heart failure]

S P Salikova1, A A Stadnikov, A P Semagin

  • 1Department of Histology, Cytology and Embryology, Orenburg State Medical Academy.

Morfologiia (Saint Petersburg, Russia)
|January 18, 2003
PubMed

Insights

Chronic heart failure (CHF) progression is linked to significant changes in heart muscle cells (cardiomyocytes). These changes include cell damage and structural alterations, but not necessarily increased cell death.

Area of Science:

  • Cardiology
  • Cell Biology
  • Pathology

Context:

  • Investigates cellular changes in the right atrium auricula during chronic heart failure (CHF).
  • Utilizes light and electron microscopy for detailed ultrastructural analysis.
  • Examines myocardial tissue from patients across various stages of CHF.

Purpose:

  • To characterize the morphological alterations in cardiomyocytes (CMC) and interstitial cells in relation to CHF progression.
  • To determine if cardiomyocyte apoptosis correlates with the severity of chronic heart failure.

Summary:

  • Significant cardiomyocyte heteromorphism, including hypertrophy and organelle changes, is observed and correlates with CHF advancement.
  • Ultrastructural findings reveal sarcomere disorganization, myofibril fragmentation, and altered membrane systems (pinocytotic vesicles, caveolae, T-system tubules).
  • Apoptosis of cardiomyocytes and interstitial cells occurs, but no significant correlation with CHF stage was found.

Impact:

  • Provides detailed insights into the cellular pathology of chronic heart failure.
  • Highlights the structural remodeling of cardiomyocytes as a key feature of CHF progression.
  • Clarifies the role of apoptosis in the context of CHF severity.

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