[Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously]

The changes of the histological structure of intact skin and of the skin within the area of burn trauma, caused by treatment with methyluracil-containing ointments, were studied. Morphometric investigations employing computer technologies have been performed using "DiaMorph" device-program complex (Russia). It was established that methyluracil possessed wound-healing properties by stimulating epidermal proliferation in the zone of injury and by modifying an inflammatory reaction enhancing its fibroblastic component. Daily applications of methyluracil to intact skin for a period of half a year resulted in some reduction of reserve capabilities of cambial keratinocytes, that was objectively manifested by a decrease of epidermal germinal layer thickness.