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Expression of 1A6 gene and its correlation with intestinal gastric carcinoma
Yi-Qiang Liu1, Hong Zhao, Tao Ning
1Department of Pathology, Peking University School of Oncology, Beijing 100036, China.
Aim:
To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.
Methods:
One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.
Results:
The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant.
Conclusion:
As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.