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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Protective effect of enterosgel on rat liver lysosomes during cytostatic treatment
O R Grek1, S V Mishenina, A B Pupyshev
1Department of Pharmacology, Central Research Laboratory, Novosibirsk State Medical Academy.
Bulletin of Experimental Biology and Medicine
|January 21, 2003
Abstract:
Polychemotherapy with a complex of cytostatics (cyclophosphamide, doxorubicin, vincristine, prednisolone) induces progressive damage to hepatocyte membranes, which manifested in labilization of lysosomes and activation of lysosomal enzymes and serum transaminases. Enterosgel stabilized liver lysosomes and reduced manifestation of hepatocyte cytolysis.