[Anti-erythrocyte alloimmunization in an obstetrical milieu. Study of 2093 cases]

From January 94 to December 99, we were looking for an anti-erythrocytary immunization at 2093 women followed up in obstetrical environment. As a whole, 2232 researches of antierythrocytary antibodies (RAI) were carried out, say 1.07 RAI/women. These RAI concerned, in 4 cases out of 5, some Rh- women having an Rh+ spouse. The results were positive among 78 women, say 3.73% and 71 women having an allo-immunization antibodies (Ab), say 3.39%. The specificity of the Ab is variable: 45 anti-D, 33 Ab other specialities (C, E, K, Fya, JKb, Lua,...) and 16 positive RAI which are difficult to interpret. Besides, the immunization of women according to the number of gestations shows an increasing rate ranging from 0.27%, for a gestation to 7.44% for 4 gestations or more. Finally, the prophylaxis of the allo-immunization to the antigen D, possible thanks to the immunoglobulins anti-D, was only active among 42.13% of Rh women having a Rh+ spouse.