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Updated: Sep 27, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
Published on: January 8, 2015
[Prion diseases: current views]
Abstract:
This is a review of the problem. The above diseases represent a peculiar type of fatal neurodegenerative diseases of man and animals provoker of which is prion--a low molecular anucleinic protein resistant to inactivation. Human prior diseases include fatal familial sleeplessness, Kreutzfeldt-Jakob disease, kuru, Gerstmann-Streussler-Sheinker's syndrome, etc. Prion proteins possess a characteristic capacity to change a tertiary conformation resulting in the formation of a pathological form of protein having infectious properties. Pathogenesis, morphological and clinical manifestations as well as principles of diagnosis and treatment of these diseases are discussed.
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