Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

Peter G Clifton1, Michelle D Lee, Elizabeth M Somerville

  • 1Experimental Psychology, University of Sussex, Brighton BN1 9QG, UK. pete@biols.susx.ac.uk

The European Journal of Neuroscience
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An online study of associations between physical activity, cognitive functioning and food choice.

Appetite·2026
Same author

The cost-effectiveness of predictive algorithm guided primary antidepressant treatment: economic evaluation of the multinational PReDicT randomised controlled trial.

BJPsych open·2026
Same author

Inhibitory control mediates the effect of high intensity interval exercise on food choice.

Appetite·2024
Same author

When a test is more than just a test: Findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial).

Comprehensive psychiatry·2024
Same author

Self-identified strategies to manage intake of tempting foods: cross-sectional and prospective associations with BMI and snack intake.

Public health nutrition·2024
Same author

Interoceptive accuracy mediates the longitudinal relationship between attention deficit hyperactivity disorder (ADHD) inattentive symptoms and disordered eating in a community sample.

Physiology & behavior·2023
Same journal

The Brain Response to Reflectional Symmetry Is Not Uniquely Preattentive.

The European journal of neuroscience·2026
Same journal

The Design of Music Rhythm-Based Optical-Magnetic Stimulator and Its Study on LTP/LTD in the CA1 Region of the Hippocampus.

The European journal of neuroscience·2026
Same journal

The Inspiring Journeys of Women in Science.

The European journal of neuroscience·2026
Same journal

Gaining Insight Into the Nonfocality of Beta Oscillation Suppression Along the Sensorimotor Cortex Using Corticomuscular Coherence.

The European journal of neuroscience·2026
Same journal

Human Steering Control Under Unpredictable Disturbances.

The European journal of neuroscience·2026
Same journal

Human Single-Neuron Responses to Multi-Feature Auditory Deviants: Evidence From Medial Temporal Lobe.

The European journal of neuroscience·2026
See all related articles

Serotonin1B (5-HT1B) receptor knockout mice exhibit altered serotonin2C (5-HT2C) receptor functions due to long-term adaptations. These findings highlight compensatory mechanisms in 5-HT1B receptor loss impacting pharmacological responses.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Null mutant (knockout) mice are valuable in psychopharmacology.
  • These models can exhibit complex adaptations to genetic mutations.
  • Understanding these adaptations is crucial for interpreting experimental results.

Purpose of the Study:

  • To investigate adaptations in serotonin2C (5-HT2C) receptor-mediated functions in serotonin1B (5-HT1B) receptor knockout (KO) mice.
  • To determine if observed effects are due to long-term adaptation or short-term interactions.
  • To examine the hypothalamic c-fos response to 5-HT2C receptor agonists in 5-HT1B KO mice.

Main Methods:

  • Administration of 5-HT2C receptor agonists to 5-HT1B KO and wildtype (WT) mice.
  • Measurement of food intake and locomotor activity.

Related Experiment Videos

  • Assessment of hypothalamic c-fos expression.
  • Pretreatment of WT mice with a 5-HT1B receptor antagonist.

    • Main Results:

    • 5-HT1B KO mice showed reduced responses to 5-HT2C receptor agonists regarding food intake and locomotion.
    • These effects were not due to altered drug disposition.
    • Responses were not mimicked by acute 5-HT1B receptor antagonism in WT mice.
    • 5-HT1B KO mice exhibited a lowered hypothalamic c-fos response to 5-HT2C receptor agonists.

    Conclusions:

    • Constitutive loss of 5-HT1B receptors leads to compensatory adaptations in 5-HT2C receptor functions.
    • These adaptations influence the pharmacological responses observed in 5-HT1B KO mice.
    • Compensatory mechanisms are critical determinants of altered responses in knockout models.