Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory traces unbound.

Karim Nader1

  • 1Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1. nader@hebb.psych.mcgill.ca

Trends in Neurosciences
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

Recent research challenges the long-held belief that memories become permanently fixed. Reactivating consolidated memories can make them labile again, allowing for modification, strengthening, or even erasure, suggesting a dynamic memory system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.

Aging cell·2025
Same author

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2024
Same author

KIBRA anchoring the action of PKMζ maintains the persistence of memory.

Science advances·2024
Same author

Network-level changes in the brain underlie fear memory strength.

eLife·2023
Same author

The potential of carbon-based nanomaterials in hepatitis C virus treatment: a review of carbon nanotubes, dendrimers and fullerenes.

Discover nano·2023
Same author

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.

Neuron·2023
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same journal

The neural basis of laughter.

Trends in neurosciences·2026
See all related articles

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Molecular Biology

Background:

  • Long-standing dogma suggests memories become permanently stable after initial encoding.
  • This stability was thought to be irreversible, forming the basis of memory consolidation.

Purpose of the Study:

  • To investigate the hypothesis that reactivated consolidated memories regain a labile state.
  • To explore the dynamic nature of memory storage and modification.

Main Methods:

  • Utilized established memory research paradigms.
  • Employed advanced neurobiological technologies to analyze memory dynamics.

Main Results:

  • Data provide strong support for memory reactivation inducing a labile state.

Related Experiment Videos

  • Evidence suggests memories can be modified, strengthened, or erased post-reactivation.

    • Conclusions:

    • The neurobiological basis of memory is highly dynamic, not static.
    • This challenges the century-old dogma of permanent memory consolidation.