Related Experiment Video
Updated: Aug 19, 2026
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
Published on: September 2, 2010
[Expression and significance of urokinase-type plasminogen activator in medulloblastoma]
1Department of Neurosurgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Objective:
To detect the expression and evaluate the clinical significance of urokinase-type plasminogen activator (uPA) in medulloblastoma.
Methods:
LSAB (labelled streptavidin biotin method) immunohistochemical technique was applied for detecting the expression of uPA in 50 patients with medulloblastoma, and a follow-up survey with Cox regression analysis was made.
Results:
The staining for uPA was localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA was an independent prognostic factor affecting survival and it had a negative correlation with the prognosis.
Conclusion:
uPA appears to be an independent marker for predicting the prognosis of medulloblastoma.
