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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[Changes in plasma concentration of interleukin-6 in elderly patients with coronary artery disease complicated with

X Q Wang1, Z J Jian, J C Xie

  • 1Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|January 23, 2003
PubMed

Insights

Elevated plasma interleukin-6 (IL-6) levels indicate more severe coronary artery disease (CAD) with heart failure. Higher IL-6 correlates with poorer left ventricular ejection fraction and predicts re-hospitalization risk in CAD patients.

Area of Science:

  • Cardiology
  • Immunology
  • Geriatrics

Context:

  • Coronary artery disease (CAD) is a leading cause of mortality in the elderly.
  • Heart failure (HF) is a common complication of CAD, associated with increased morbidity and mortality.
  • Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in cardiovascular disease pathogenesis.

Purpose:

  • To investigate plasma interleukin-6 (IL-6) concentrations in elderly patients with coronary artery disease (CAD).
  • To compare IL-6 levels between CAD patients with and without heart failure, and with normal subjects.
  • To explore the correlation between IL-6 levels, left ventricular ejection fraction (LVEF), and risk of re-hospitalization in CAD patients.

Summary:

  • Plasma IL-6 levels were significantly higher in elderly CAD patients with heart failure compared to those without heart failure and normal controls.
  • A significant negative correlation was observed between plasma IL-6 concentration and left ventricular ejection fraction (LVEF) (r = -0.60, P < 0.01).
  • CAD patients with severe heart failure requiring re-hospitalization exhibited significantly higher plasma IL-6 levels than those without readmission (P < 0.01).

Impact:

  • Plasma IL-6 concentration may serve as a valuable biomarker for assessing disease severity in elderly CAD patients with heart failure.
  • IL-6 levels could offer prognostic information, aiding in the prediction of adverse outcomes and guiding clinical management in CAD.
  • These findings highlight the role of inflammation, as indicated by IL-6, in the progression and prognosis of CAD with heart failure.
Abstract

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