Related Experiment Video
Updated: Sep 27, 2026
Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles
Published on: June 8, 2012
[Expression of platelet-derived growth factor-b and transforming growth factor-beta 1 in the alveolar macrophages of
1Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To investigate the role of alveolar macrophages in airway remodeling in asthma.
Method:
Sixteen Wistar rats were divided into two groups: control group and asthmatic group. The expressions of platelet-derived growth factor-b (PDGF-b) and transforming growth factor-beta. (TGF-beta 1) in the alveolar macrophages of allergic rats were detected by immunohistochemistry and in situ hybridization.
Results:
The expression of TGF-beta 1 in alveolar macrophages in allergic group was increased in both protein level (P < 0.05) and TGF-beta 1 mRNA(P < 0.01); but the expression of PDGF-b had no difference between the two groups.
Conclusion:
The alveolar macrophages may involve in the airway remodeling of asthma.
