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A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
Published on: March 23, 2018
[Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance]
1Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objective:
To investigate the effects of ketamine on cardiopulmonary bypass-induced IL-6 and IL-8 response.
Methods:
Twenty-four adult patients undergoing cardiac valve replacement were divided into control and ketamine group (n = 12). In the ketamine group, 1 mg.kg-1 ketamine was infused intravenously at the beginning of operation and CBP. Plasma levenof IL-6 and IL-8 were measured at different time after induction of anesthesia.
Results:
In both groups, the levels of IL-6 and IL-8 increased significantly compared with those at the time before CBP (P < 0.05), but compared with those in control groups, IL-6 and IL-8 levels decreased obviously in ketamine group(P < 0.05).
Conclusions:
Ketamine is effective to reduce cardiopulmonary bypass-induces IL-6 and IL-8 response and protect reperfusion myocardium.
