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Direct organocatalytic aldol reactions in buffered aqueous media
Armando Córdova1, Wolfgang Notz, Carlos F Barbas
1Skaggs Institute for Chemical Biology, Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Chemical Communications (Cambridge, England)
|January 23, 2003
Abstract:
Organocatalytic cross-aldol reactions catalyzed by cyclic secondary amines in aqueous media provide a direct route to a variety of aldols including carbohydrate derivatives and may warrant consideration as a prebiotic route to sugars.