Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shaping the zebrafish notochord.

Nathalia S Glickman1, Charles B Kimmel, Martha A Jones

  • 1Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.

Development (Cambridge, England)
|January 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of a Novel Video Game Platform in the Treatment of Pediatric Amblyopia.

Journal of pediatric ophthalmology and strabismus·2023
Same author

Telehealth-Guided Virtual Reality for Recovery of Upper Extremity Function Following Stroke.

OTJR : occupation, participation and health·2023
Same author

Concurrent Validity of Measures of Upper Extremity Function Derived from Videogame-Based Motion Capture for Children with Hemiplegia.

Games for health journal·2023
Same author

Transgene-mediated skeletal phenotypic variation in zebrafish.

Journal of fish biology·2020
Same author

Developmental tuning of mineralization drives morphological diversity of gill cover bones in sculpins and their relatives.

Evolution letters·2019
Same author

Upper Extremity Function Assessment Using a Glove Orthosis and Virtual Reality System.

OTJR : occupation, participation and health·2019
Same journal

Regulation of Hippo signaling by Atrophin in the developing Drosophila wing.

Development (Cambridge, England)·2026
Same journal

Retinoic acid and FGF signaling interact to control elongation and lineage specification in a mouse gastruloid model.

Development (Cambridge, England)·2026
Same journal

Expanding the C. elegans toolkit with gonad explants.

Development (Cambridge, England)·2026
Same journal

Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut.

Development (Cambridge, England)·2026
Same journal

Primordial germ cells differentially contribute to the germline in zebrafish.

Development (Cambridge, England)·2026
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
See all related articles

Mediolateral intercalation behavior (MIB) drives zebrafish notochord convergence and extension during gastrulation. However, extension can occur independently of convergence, suggesting a separate cellular mechanism controls notochord elongation.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Embryology

Background:

  • Vertebrate notochord morphogenesis is crucial for establishing the primary embryonic axis.
  • Convergence and extension movements reshape the dorsal mesoderm during gastrulation.
  • Mediolateral intercalation behavior (MIB) is a potential mechanism coupling these morphogenetic movements.

Purpose of the Study:

  • To investigate whether MIB drives early zebrafish notochord morphogenesis.
  • To quantitatively analyze cellular interactions and shape changes in the dorsal mesoderm.
  • To determine the relationship between convergence and extension in notochord development.

Main Methods:

  • 4D recordings of zebrafish embryos.
  • Quantitative analysis of local cellular interactions.

Related Experiment Videos

  • Global shape change analysis of the dorsal mesodermal field.
  • Mutational analysis.

    • Main Results:

    • MIB appears to mediate convergence and account for extension in the dorsal mesoderm.
    • Extension can be regulated separately from convergence in the notochord and somitic mesoderm.
    • Extension does not require convergence, indicating a separate cellular machine drives it.

    Conclusions:

    • A distinct cellular mechanism, separate from MIB, drives dorsal mesodermal extension in zebrafish gastrulae.
    • Redundant control of morphogenesis allows for developmental plasticity during early embryogenesis.