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[Rat submandibular gland tumor induced by 3-methylcholanthrene]
Abstract
Objective:
To study the genesis and the development of salivary gland tumor (SGT).
Methods:
SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.
Results:
32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.
Conclusion:
Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.