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Updated: Sep 27, 2026
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease
Hazel C Jones1, Barbara J Carter, Laurence Morel
1Department of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL 32610, USA. hjones@college.med.ufl.edu
Materials And Methods:
The expression and severity of hydrocephalus was characterized in LEW/Jms rats with inherited hydrocephalus.
Results:
The frequency of overt disease (lethal) was 27.7%, but varied depending on breeding line. It increased to 31.5% when rats with mild disease were included. Most breeding pairs (48/51) produced hydrocephalic offspring with significantly more males than females affected. Some adult rats were also found to have mild (nonlethal) ventricular dilatation. When bred to Fisher F344 rats, 3% of the F(1) progeny had overt hydrocephalus, indicating that the trait is not recessive. Overt hydrocephalus was 9-20% in N(2) rats (F(1) rats x LEW/Jms). The frequency of hydrocephalus and the presence of an excess of hydrocephalic males, varied depending on the direction of the cross. Mild hydrocephalus in N(2) rats was 3.1%.
Conclusion:
It is concluded that the inheritance of hydrocephalus in LEW/Jms strain is probably not mendelian recessive but may be semidominant or involve more than one gene and has a male bias indicating possible linkage to sex chromosomes.
