[Development of integrated capillary electrophoresis chips]

Capillary electrophoresis in its different operation modes has been demonstrated that it is suitable to be integrated into a planar microdevice which is called integrated capillary electrophoresis chip (ICE chip) or microchip. The use of microfabrication and micromachining allows the integration of complex channel nets and functional units such as pre- and post-column reaction chambers on a single chip, providing good sensitivity and high separation efficiency with low reagent consumption and short analysis time. In the last 10 years an important number of publications have been reported in this area. In the present paper, the development and applications are systematically reviewed with 39 references.