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Usefulness of AgNOR counts in diagnosing epithelial dysplasia
Jay G Ray1, Amit Chattopadhyay, Daniel J Caplan
1Department of Oral Pathology and Microbiology, Dr R Ahmed Dental College and, Hospital, Kolkata, India.
Background:
Diagnosis of epithelial dysplasia has traditionally been subjective, and there is a need for a quantifiable and useful test.
Methods:
In a double blind study, clinical leukoplakias from 52 people were diagnosed for presence (DLK) or absence (NDLK) of epithelial dysplasia using hematoxylin and eosin (H&E) stain as a gold standard criterion, and results were compared against their mean silver stainable nucleolar organizer region (AgNOR) counts. We used mean AgNOR count cut-point of 2.37 from our prior report as the diagnostic threshold (mean >or= 2.37 being DLK and mean < 2.37 being NDLK).
Results:
The two methods (H&E and AgNOR) disagreed in 37% of the diagnoses. Both NDLK and DLK had high AgNOR counts. P-AgNOR was non-contributory for diagnosing epithelial dysplasia.
Conclusions:
Mean AgNOR count can be a useful tool in definitive diagnosis of epithelial dysplasia.
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