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Related Experiment Videos

Interactions between calcium release pathways: multiple messengers and multiple stores.

A Galione1, G C Churchill

  • 1Department of Pharmacology, Oxford University, Mansfield Road, OX1 3QT, Oxford, UK. antony.galione@pharm.ox.ac.uk

Cell Calcium
|January 25, 2003
PubMed
Summary
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Cyclic adenosine diphosphate ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are key calcium (Ca2+) messengers. They work with myo-inositol 1,4,5-trisphosphate (IP3) to generate complex Ca2+ signaling patterns in cells.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Physiology

Background:

  • Calcium ions (Ca2+) are crucial intracellular messengers.
  • Complex Ca2+ signaling patterns are generated by various molecules.
  • Cyclic adenosine diphosphate ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as significant Ca2+ releasing messengers.

Purpose of the Study:

  • To review the roles of cADPR and NAADP in Ca2+ signaling.
  • To discuss the interplay between different Ca2+ messengers and release channels.
  • To explore how cells generate distinct Ca2+ signaling signatures.

Main Methods:

  • Literature review of Ca2+ signaling mechanisms.
  • Analysis of the distinct structures and functions of cADPR, NAADP, and IP3.

Related Experiment Videos

  • Examination of Ca2+ release channels (e.g., RYRs) and Ca2+ stores (e.g., ER, acidic granules).

    • Main Results:

    • cADPR enhances ryanodine receptor sensitivity, prolonging Ca2+ signals via Ca2+-induced Ca2+ release (CICR).
    • NAADP triggers local Ca2+ signals from acidic stores, which can be amplified by CICR.
    • IP3 and cADPR mobilize Ca2+ from the endoplasmic reticulum, while NAADP acts on different stores.

    Conclusions:

    • Multiple Ca2+ mobilizing messengers (cADPR, NAADP, IP3) and Ca2+ stores contribute to specific Ca2+ signaling patterns.
    • The interplay between these messengers and release mechanisms allows for diverse cellular responses.
    • Cells utilize distinct combinations of messengers to produce unique Ca2+ signaling signatures based on stimuli.