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Related Experiment Video

Updated: Feb 13, 2026

1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions
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Ebselen has lithium-like effects on central 5-HT2A receptor function.

I Antoniadou1,2, M Kouskou1, T Arsiwala1

  • 1Department of Pharmacology, University of Oxford, Oxford, UK.

British Journal of Pharmacology
|March 1, 2018
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Summary
This summary is machine-generated.

Ebselen, an antioxidant, mimics lithium

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Area of Science:

  • Neuropharmacology
  • Molecular Biology
  • Biochemistry

Background:

  • Lithium's antidepressant effects are linked to inositol monophosphatase (IMPase) inhibition.
  • Ebselen, an antioxidant, also inhibits IMPase.
  • The 5-HT2A receptor, a Gq-protein coupled receptor, is implicated in lithium's actions.

Purpose of the Study:

  • To investigate ebselen's effects on 5-HT2A receptor function.
  • To compare ebselen's actions with lithium in relevant models.
  • To explore ebselen's potential as an antidepressant augmenting agent.

Main Methods:

  • Assessed 5-HT2A receptor function in mice via behavioral and molecular responses to agonists.
  • Administered ebselen and lithium acutely and repeatedly.
  • Tested ebselen's interaction with citalopram (SSRI) in microdialysis experiments.

Main Results:

  • Ebselen and lithium inhibited 5-HT2A receptor-mediated behavioral and gene expression responses.
  • Ebselen enhanced SSRI-induced serotonin release and increased brain serotonin synthesis.
  • A selective IMPase inhibitor, but not a GSK inhibitor, mimicked ebselen's effect on DOI response.

Conclusions:

  • Ebselen exhibits lithium-mimetic effects on 5-HT2A receptor function, likely via IMPase inhibition.
  • These findings support clinical trials of ebselen for mood disorders.
  • Ebselen may serve as an effective antidepressant augmenting agent.