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Updated: Aug 18, 2026

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
Published on: July 22, 2013
Glucose regulation and oxidative stress in healthy centenarians
Michelangela Barbieri1, Maria Rosaria Rizzo, Daniela Manzella
1Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, IV Divisione di Medicina Interna, Piazza Miraglia 2, I-80138 Napoli, Italy.
Abstract:
Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
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