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Updated: Aug 2, 2026
09:55
Force-Clamp Rheometry for Characterizing Protein-based Hydrogels
Published on: August 21, 2018
Volumetric properties of proteins
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario Canada. chalikan@phm.utoronto.ca
Annual Review of Biophysics and Biomolecular Structure
|January 25, 2003
Summary
Volumetric techniques offer valuable insights into protein folding and binding by analyzing hydration and packing. Recent advancements in sensitive instrumentation are enhancing these studies for protein interactions.
Area of Science:
- Biophysics
- Biochemistry
- Structural Biology
Background:
- Protein folding and binding are central to biological function.
- Understanding intra- and intermolecular interactions is crucial for protein stability.
- Volumetric techniques have a long history but are underutilized in protein studies.
Purpose of the Study:
- To review the application of volumetric properties in protein research.
- To highlight recent progress in using volumetric data for protein studies.
- To explore volumetric insights into protein folding, binding, and interactions.
Main Methods:
- Utilizing volumetric measurements to characterize protein systems.
- Employing advanced, highly sensitive volumetric instrumentation.
- Analyzing volumetric properties of proteins and low-molecular-weight analogs.
Main Results:
- Volumetric techniques provide insights into protein hydration and intraglobular packing.
- Recent advancements enable more sensitive volumetric investigations.
- Volumetric data aids in studying protein conformational transitions and interactions.
Conclusions:
- Volumetric measurements are a powerful, yet underexplored, tool for protein science.
- Continued development of volumetric instrumentation will advance protein folding and binding research.
- This review emphasizes the growing importance of volumetric studies in understanding protein systems.
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01:22Protein Folding
Overview
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02:21Globular and Fibrous Proteins
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01:24Protein Organization
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The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
01:25Protein Folding
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Protein Structure Is Critical to Its Biological Function
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