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Calcospherules associated with juvenile hyaline fibromatosis
Christine J Ko1, Ronald J Barr
1Department of Dermatology and Dermatopathology Laboratory, University of California, Irvine, USA.
The American Journal of Dermatopathology
|January 25, 2003
Abstract:
Juvenile hyaline fibromatosis is a rare autosomal recessive genodermatosis that manifests with 1 to 5 cm skin tumors, gingival hyperplasia, osteolytic bone lesions, and joint contractures. The skin tumors are most often located on the head and periarticular extremities. A case of juvenile hyaline fibromatosis with typical skin tumors that on biopsy exhibited basophilic calcospherules is presented. Although noted in a single case, these structures may be a novel, yet helpful, diagnostic marker.