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[Addition internal standard method in chromatographic quantitative analysis].

Y J Zheng1, Y Kang, Y Z Feng

  • 1College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China. zyj@mail.qqhru.edu.cn

Se Pu = Chinese Journal of Chromatography
|January 28, 2003
PubMed
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This study introduces the addition internal standard method, a novel chromatographic quantitation technique. It overcomes limitations of the traditional internal standard method by combining it with the addition method for improved accuracy and applicability.

Area of Science:

  • Analytical Chemistry
  • Chromatography

Context:

  • Traditional internal standard methods in chromatography face challenges with component separation and standard selection.
  • These limitations can restrict the convenience and applicability of quantitative analysis.

Purpose:

  • To develop a new quantitative method, the addition internal standard method, by integrating the internal standard and addition methods.
  • To define the theoretical basis, operational steps, and suitable conditions for this novel technique.

Summary:

  • The addition internal standard method is proposed as a solution to the limitations of conventional internal standard methods in chromatography.
  • This method combines principles of both internal standard and addition techniques, offering broader applicability.
  • The paper details the theoretical foundation, operational procedures, and suitability for chromatographic and polarographic quantitation.

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Impact:

  • The addition internal standard method offers a more flexible and potentially more accurate approach to quantitative analysis.
  • Its principles are applicable beyond chromatography, including techniques like polarography.
  • This advancement provides analytical chemists with a valuable new tool for sample quantification.