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[Effect of BSAP/Pax-5 on the development, proliferation and differentiation of B lymphocyte cell]

Y Q Tan1, Y X Zhang

  • 1Beijing Institute of Toxicology and Pharmacology, Academy of Military Medical Science, Beijing 100850.

BSAP, a B cell lineage-specific activator protein, is a nucleus transcription factor and is encoded by the Pax-5 gene. It is a critical modulator of B cell development, proliferation and differentiation. BSAP also influences B cell immunoglobulin secretion at later stages of B cell differentiation.

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