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Published on: August 8, 2022

Hereditary protein s deficiency with a history of recurrent myocardial infarction

Nobuyuki Ogasawara1, Yoshiyuki Kijima, Shinpei Ike

  • 1Department of Cardiology, Higashi-osaka City General Hospital, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|January 28, 2003
PubMed

Insights

Hereditary protein S deficiency, a condition affecting blood coagulation, was linked to recurrent myocardial infarction in a 58-year-old man. This highlights a potential connection between clotting disorders and heart attacks.

Area of Science:

  • Biochemistry
  • Hematology
  • Cardiology

Background:

  • Protein S is a crucial vitamin K-dependent plasma protein regulating blood coagulation.
  • It functions by activating protein C, another key vitamin K-dependent plasma protein.
  • Deficiencies in Protein S can impair the natural anticoagulant pathway.

Observation:

  • A 58-year-old male patient presented with a history of hereditary protein S deficiency.
  • The patient experienced recurrent episodes of acute myocardial infarction.
  • These cardiac events occurred at ages 52 and 58.

Findings:

  • The case report details a patient with hereditary protein S deficiency.
  • The patient suffered multiple myocardial infarction events.
  • This suggests a potential link between protein S deficiency and cardiovascular events.

Implications:

  • Hereditary protein S deficiency may be an underrecognized risk factor for myocardial infarction.
  • Further research is warranted to explore the prothrombotic mechanisms in protein S deficiency.
  • This case underscores the importance of considering coagulation disorders in patients with recurrent cardiovascular events.

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