Related Experiment Video
Updated: Sep 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Perfusion-weighted dynamic susceptibility (DSC) MRI: basal ganglia hemodynamic changes after apomorphine in
L Brusa1, A Bassi, M Pierantozzi
1IRCCS Fondazione S. Lucia, Via Ardeatina 306, I-00179 Rome, Italy.
Abstract:
Relative regional blood flow of basal ganglia was studied by means of perfusion-weighted dynamic susceptibility (DSC) MRI. Parkinson's disease (PD) patients showed a significant inter-hemispheric asymmetry due to a higher perfusion in the more affected side, while normal subjects did not. PD exhibited an abnormal "asymmetry index" in the measured nuclei. A second DSC-MRI examination performed after subcutaneous apomorphine administration did not show any significant asymmetry in PD patients. DSC-MRI of basal ganglia confirms the asymmetry observed in PET studies of PD patients, suggesting that this method is a promising and low-cost technique in neurodegenerative diseases.
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