Related Experiment Video
Updated: Aug 2, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[An improvement on determination of the related substances in vindesine sulfate and its injection]
Abstract:
A new method for the analysis of related substances in vindesine sulfate and its injection to improve the ability of separation by RP-HPLC was established. The separation was achieved by applying a reversed-phase C18 column (150 mm x 4.6 mm i.d.) and a mixture of V(MeOH):V(buffer solution) = 70:30 as mobile phase. The buffer solution was an aqueous solution of volume fraction 1.5% diethylamine adjusted to pH 7.5 with phosphoric acid. The UV-detector was set at 267 nm. Four related substances were separated from vindesine within thirteen minutes. The tailing factor of the peak of vindesine is 1.00-1.05. The results showed that this method is more efficient for separating the related substances in vindesine sulfate than the conventional method.
More Related Videos
07:28Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron
Published on: September 23, 2020
08:24Development and Standardization of an Ex Vivo Micromethod for Intracellular Quantification of Vincristine in Primary ALL Cells by LC-MS/MS
Published on: January 23, 2026
Related Concept Videos
Bioequivalence studies: Biowaivers
In Vitro Drug Release Testing: Overview, Development and Validation
In Vitro Drug Dissolution: Alternative Methods
Clinically Relevant Drug Product Specifications: Methods of Establishment
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Drug Accumulation During Multiple Dosing: Repetitive IV Injections