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Vitamin C and E supplements improve the impaired antioxidant status and decrease plasma lipid peroxides in
Jane C.-J. Chao1, Mi Duo Yuan, Pei Yuan Chen
1Graduate Institute of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan
The Journal of Nutritional Biochemistry
|January 29, 2003
Summary
Supplementing hemodialysis patients with vitamin C and E improved their antioxidant status and reduced harmful lipid peroxides. This combination therapy showed lasting benefits even after supplementation ceased, enhancing overall well-being.
Area of Science:
- Biochemistry
- Clinical Nutrition
- Nephrology
Background:
- Hemodialysis patients exhibit compromised antioxidant systems, evidenced by lower vitamin C, glutathione, and total antioxidant status, alongside elevated lipid peroxides compared to healthy controls.
- Plasma levels of vitamin C and total antioxidant status significantly decline during hemodialysis sessions.
Purpose of the Study:
- To investigate the effects of vitamin C and/or vitamin E supplementation on the antioxidant system in hemodialysis patients.
- To evaluate the impact of combined vitamin C and E supplementation on oxidative stress markers.
Main Methods:
- A 6-week supplementation study involving 38 hemodialysis patients divided into placebo, vitamin C, vitamin E, and combined vitamin C + E groups.
- Oral administration of three capsules (placebo or antioxidants) three times weekly post-hemodialysis.
- Comparison of antioxidant markers and lipid peroxides between supplemented groups and a placebo group, as well as against a healthy control group.
Main Results:
- Combined vitamin C and E supplementation significantly increased plasma vitamin C, vitamin E, erythrocyte glutathione, and plasma total antioxidant status.
- The vitamin C + E group demonstrated significant inhibition of plasma lipid peroxides compared to the placebo group.
- Elevated levels of vitamin C, vitamin E, and total antioxidant status, with reduced lipid peroxides, persisted for at least two weeks after discontinuing supplementation in the combined group.
Conclusions:
- Antioxidant vitamin supplementation, particularly the combination of vitamin C and E, can effectively improve the antioxidant status in hemodialysis patients.
- Combined vitamin C and E supplementation helps mitigate oxidative stress by decreasing lipid peroxides in hemodialysis patients.
- The benefits of combined vitamin C and E supplementation on antioxidant status and lipid peroxide levels are sustained even after the cessation of treatment.