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Updated: Sep 27, 2026

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS)
Published on: May 20, 2013
Characterization of soluble polymer supported organic compounds by LC/electrospray ionization MS toward a complete
C Enjalbal1, F Lamaty, P Sanchez
1Laboratoire des Amino acides, Peptides et Protéines, UMR 5810, CNRS-Universités Montpellier I & II, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Abstract:
In the case of a soluble polymer supported synthesis, the tuning of the support solubility depending on the solvent offers new opportunities for combinatorial chemistry for two reasons. First, organic syntheses in solution are generally easily translated on a soluble polymer supported substrate. Second, complete automation of the three successive steps of combinatorial chemistry (synthesis, analytical control, biological test) is approached without releasing the synthesized compound from the support. We report in this paper the preliminary results toward automation of both soluble polymer supported syntheses and their subsequent monitoring by ESI mass spectrometry.
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