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Related Experiment Videos

Pediatric reference ranges for zinc protoporphyrin.

Offie Porat Soldin1, Maureen Miller, Steven J Soldin

  • 1Soldin Research and Consultants, Inc., Bethesda, MD, USA. offie@gwu.edu

Clinical Biochemistry
|January 30, 2003
PubMed
Summary

This study establishes pediatric reference ranges for zinc protoporphyrin (ZPP) in children aged 0-17 years. Findings detail ZPP levels across different age groups and genders, crucial for clinical interpretation.

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Area of Science:

  • Clinical Chemistry
  • Pediatric Hematology
  • Biochemical Reference Intervals

Background:

  • Zinc protoporphyrin (ZPP) is a biomarker indicative of iron status and lead exposure.
  • Establishing accurate pediatric reference ranges for ZPP is essential for diagnosing and monitoring various health conditions in children.
  • Existing ZPP reference ranges may not adequately cover the diverse pediatric population.

Purpose of the Study:

  • To determine and define pediatric reference ranges for zinc protoporphyrin (ZPP) in children from birth to 17 years of age.
  • To provide age- and sex-specific ZPP percentiles for improved clinical utility.
  • To establish a robust dataset for ZPP analysis in a large pediatric cohort.

Main Methods:

  • Analysis of blood specimens from 6,478 pediatric patients (0-17 years) collected between January 2001 and June 2002.

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  • Utilized a computer-adapted Hoffman approach for statistical analysis of ZPP data.
  • Data stratified by age groups (0-12 months, 13-24 months, 5-9 years, 10-17 years) and gender.

    • Main Results:

    • Established 2.5th and 97.5th percentiles for ZPP across pediatric age groups and genders.
    • ZPP 97.5th percentiles showed a decrease in older age groups (e.g., 5-9 years) compared to infants.
    • Median ZPP levels were highest in the 0-12 months age group for both females (25.5 microg/dL) and males (21.5 microg/dL).

    Conclusions:

    • The study provides comprehensive pediatric reference ranges for zinc protoporphyrin (ZPP).
    • These reference ranges highlight significant variations in ZPP levels by age and gender.
    • The findings support better interpretation of ZPP test results in pediatric clinical practice.