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Updated: Aug 8, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
[Werner's disease presenting as ischemic mitral incompetence]
B Jamet1, E Wagner, S Tassan Mangina
1CHU Reims, Hôpital Robert Debré, Département de Cardiologie et Pathologie Vasculaire, Rue du Général Koenig, 51092 Reims.
Abstract:
Werner's syndrome or progeria, described for the first time in 1886, is a rare disease with autosomal recessive transmission, characterized by premature ageing of connective tissues. About 200 cases have since been reported in the literature. Most patients die young, generally from heart failure due to early coronary atherosclerosis [1]. The authors report the case of a 46-year-old woman presenting with cardiovascular abnormalities, unusual for her age, associated with a particular morphotype belonging to Werner's syndrome.
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