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Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3
Mizio Matteucci1, Gurdip Bhalay, Mark Bradley
1Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton S017 1BJ, United Kingdom.
Organic Letters
|January 31, 2003
Abstract:
[reaction: see text] Catalytic Sc(OTf)(3) greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl-aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.