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Total synthesis of the formamicin aglycon, formamicinone
Brad M Savall1, Nicolas Blanchard, William R Roush
1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Organic Letters
|January 31, 2003
Abstract:
[structure: see text] The total synthesis of formamicinone (2), the aglycone of formamicin (1), has been accomplished via the late-stage Suzuki cross-coupling of fragments 5 and 6, the macrolactonization of seco ester 14, and the Mukaiyama aldol reaction of aldehyde 3 and methyl ketone 4. An efficient and highly stereoselective second generation synthesis of vinyl iodide 6 is also described.