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Human c-fos promoter mediates high-level, inducible expression in various mammalian cell lines

Jing-Xiu Bi1, Petra Buhr, An-Ping Zeng

  • 1Biochemical Engineering Division, GBF - German Research Centre for Biotechnology, Braunschweig, D-38124 Germany.

Biotechnology and Bioengineering
|January 31, 2003
PubMed

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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