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Published on: December 26, 2017
[Phagocytic activity of mouse peritoneal macrophages under administration of bacterial vaccines and prospidin]
1Kharkov State Medical University, 4 Lenin Pr., Kharkov, 61078, Ukraine.
Abstract:
Phagocytic activity of peritoneal macrophages in cases of separate and combined injections of killed bacterial vaccines and prospidin has been studied in the work. As a result of researches conducted, it has been found out that the injection of vaccines together with prospidin makes it possible to reduce an inhibiting effect of prospidin on phagocytic activity of monocyte-macrophagal cells; first of all it concerns their digestive activity. Thus, the immunodepressing effect of antiblastome drugs may be reduced with the help of injection of killed bacterial vaccines which stimulate nonspecific factors of organism protection, including antineoplastic ones.
Insights
Killed bacterial vaccines can counteract the immunosuppressive effects of antiblastome drugs like prospidin. Combining vaccines with prospidin preserves macrophage phagocytic and digestive activity, enhancing the body's natural defenses.
Area of Science:
- Immunology
- Pharmacology
- Oncology
Background:
- Prospidin is an antiblastome drug with potential immunosuppressive effects.
- Phagocytic activity of macrophages is crucial for immune response.
- The interaction between antiblastome drugs and immune cells requires further investigation.
Purpose of the Study:
- To investigate the effect of combined administration of killed bacterial vaccines and prospidin on macrophage phagocytic activity.
- To determine if bacterial vaccines can mitigate the immunosuppressive effects of prospidin.
Main Methods:
- Peritoneal macrophages were isolated from experimental subjects.
- Phagocytic activity, including digestive activity, was assessed.
- Subjects received separate or combined injections of killed bacterial vaccines and prospidin.
Main Results:
- Combined injection of vaccines and prospidin reduced the inhibitory effect of prospidin on macrophage phagocytic activity.
- Digestive activity of monocyte-macrophagal cells was particularly preserved.
- Killed bacterial vaccines stimulated nonspecific protective factors, including antineoplastic ones.
Conclusions:
- Killed bacterial vaccines can mitigate the immunosuppressive effects of antiblastome drugs.
- This approach may enhance the body's natural antineoplastic defenses.
- Combining immunostimulatory vaccines with chemotherapy warrants further research.
