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Related Experiment Videos

Risperidone induced galactorrhea: a case analysis.

Jaishree Hariharan1, Jamil Mohsin

  • 1Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, Wis., USA.

WMJ : Official Publication of the State Medical Society of Wisconsin
|February 1, 2003
PubMed
Summary

This study documents galactorrhea and amenorrhea in patients treated with risperidone, linked to elevated prolactin levels. Symptoms resolved upon drug cessation, highlighting a critical side effect of this antipsychotic medication.

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Area of Science:

  • Endocrinology
  • Neuropharmacology
  • Reproductive Medicine

Background:

  • Risperidone is a widely prescribed atypical antipsychotic medication.
  • Hyperprolactinemia is a known potential side effect of certain antipsychotic drugs.
  • Understanding drug-induced endocrine disturbances is crucial for patient management.

Observation:

  • A patient developed galactorrhea (lactation) and amenorrhea (absence of menstruation) after six months of risperidone treatment.
  • These symptoms were directly associated with elevated serum prolactin levels.
  • The endocrine side effects resolved completely after discontinuing risperidone therapy.

Findings:

  • Risperidone treatment can lead to significant hyperprolactinemia.
  • Hyperprolactinemia induced by risperidone can manifest as reproductive hormonal disturbances.

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  • Drug discontinuation is an effective strategy for managing these adverse effects.

    • Implications:

    • Clinicians should monitor for endocrine side effects in patients on risperidone.
    • Elevated prolactin levels and associated symptoms necessitate careful evaluation and potential medication adjustment.
    • Further research into the long-term sequelae of risperidone-induced hyperprolactinemia is warranted.