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Related Experiment Videos

Current targets for anticancer drug discovery.

Nguyen-Hai Nam1, Keykavous Parang

  • 1Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA. nhnam@hotmail.com

Current Drug Targets
|February 1, 2003
PubMed
Summary

Discovering novel anticancer drugs is crucial. This review highlights key molecular targets, including growth factors and protein kinases, vital for inhibiting tumor growth and improving cancer treatment efficacy.

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Area of Science:

  • Oncology and Pharmacology
  • Molecular Biology and Drug Discovery

Background:

  • The urgent need for less toxic, more effective cancer therapeutics drives research into novel drug targets.
  • Inhibition of tumor angiogenesis, a critical process for tumor growth and metastasis, is a major focus in cancer drug discovery.

Purpose of the Study:

  • To provide a comprehensive summary of key molecular targets in contemporary anticancer drug design and discovery.
  • To highlight recent advances in targeting molecules involved in angiogenesis, cell proliferation, and survival.

Main Methods:

  • Review of current literature on molecular targets for cancer therapy.
  • Analysis of validated targets including growth factors, receptor tyrosine kinases, non-receptor kinases, cell cycle regulators, and apoptosis modulators.

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Main Results:

  • Identified key targets: fibroblast growth factor, platelet-derived growth factor, vascular endothelial growth factor, matrix metalloproteinases, cell adhesion molecules, Bcl-Abl, Src kinases, cyclin-dependent kinases, and apoptosis modulators.
  • Highlighted other significant targets such as protein farnesyltransferase, histone deacetylase, and telomerase.
  • Emphasized the importance of these targets in cellular signaling and cancer progression.

Conclusions:

  • Numerous molecular targets are under investigation for anticancer drug development, offering diverse strategies for inhibiting tumor progression.
  • Targeting angiogenesis, protein kinases, cell cycle regulation, and apoptosis pathways represents promising avenues for novel cancer therapeutics.