Related Experiment Videos
Third model of the undulation pump total artificial heart.
Yusuke Abe1, Tsuneo Chinzei, Takashi Isoyama
1Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-0033.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|February 1, 2003
Summary
The improved undulation pump total artificial heart (UPTAH3) enhances durability for long-term studies. This new model facilitates research into the pathophysiology of artificial heart devices.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Devices
Background:
- The undulation pump total artificial heart (UPTAH) is an implantable device for continuous blood flow.
- Previous models required durability improvements for long-term research.
- Investigating long-term pathophysiology necessitates a more robust artificial heart system.
Purpose of the Study:
- To develop a third-generation UPTAH (UPTAH3) with enhanced durability for long-term studies.
- To redesign key components for improved performance and longevity.
- To facilitate advanced research into the pathophysiology associated with artificial heart use.
Main Methods:
- Designed UPTAH3 with separated left and right undulation shafts for increased durability.
- Redesigned the undulation pumps, atrial cuffs, and outflow cannulae.
- Implemented specific dimensions: 76 mm diameter, 78-79 mm width, 292 ml total volume, 620 g weight.
Main Results:
- UPTAH3 achieved a maximum output of approximately 11 L/min against 100 mm Hg arterial pressure.
- Maximum pump efficiencies were 15% (left) and 18% (right), with a total efficiency of 11%.
- In vivo testing in 17 goats demonstrated a longest survival of 46 days.
Conclusions:
- The UPTAH3 model offers improved durability for long-term investigations.
- This enhanced total artificial heart is suitable for studying artificial heart-related pathophysiology.
- Further research utilizing UPTAH3 can advance understanding of long-term device function and patient outcomes.