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Synthesis of cyclic peptides from unprotected precursors using removable N
V M F Cardona1, O Hartley, P Botti
1Department of Medical Biochemistry, University Medical Center, Geneva, Switzerland.
Abstract:
A new method to cyclize unprotected peptides is presented. The method involves the use of a 1-phenyl-2-mercaptoethyl derivative on the N-terminal glycine. This template acts as an auxiliary thiol-containing group in order to drive cyclization with a counterpart thioester moiety on the same molecule. Subsequent facile removal of the derivative generates products with only native peptide structure. The successful, high-yield cyclization of the peptide GSPYSSDTTPA is described.